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Vaccines in Pregnancy and Infancy: National Stakeholders Meeting

May 12, 2023 @ 7:45 am - 1:00 pm UTC+0

The Makerere University-Johns University Research Collaboration (MU-JHU) in partnership with St Georges University London (SGUL) is inviting you to a special stakeholder meeting to discuss current study findings and future vaccine research in pregnant women and infants in Uganda.

The investigators will present updates on current studies within the portfolio and proposed vaccine and observational studies. You will be given an opportunity to ask questions and discuss issues related to vaccination in pregnancy and infancy.

Several studies have been underway with your support since 2018 to set the scene for maternal and infant vaccine clinical trials in Uganda. These include:

  • The PROGRESS study, to determine the incidence of Group B Streptococcal disease (GBS), colonization and neurodevelopmental impairment following infant disease. This study also includes a comprehensive overview of other pathogens that cause disease in the first months of life for which vaccines are or will soon be available to be given to pregnant women or their infants. This study will complete follow up in September 2023.
  • The WOMANPOWER study, to determine the safety and efficacy of a pertussis-containing vaccine (TDaP) given to pregnant women living with HIV. This study has completed and interim results are available.
  • The PREPARE studies: This includes the development of a pregnancy exposures registry and background rates of adverse events in sentinel sites that has also been used to monitor adverse events in pregnancy and infancy during the COVID-19 pandemic (periCOVID study). Pfizer Multivalent CPS-conjugate vaccine trial in pregnant HIV-infected and uninfected women investigating the safety and immunogenicity of the vaccine in pregnant women and the subsequent transfer of vaccine induced antibodies to their infants. Minervax GBS vaccine trial in pregnant HIV-infected and uninfected women investigating the safety and immunogenicity of the vaccine in pregnant women and the subsequent transfer of vaccine induced antibodies to their infants. This programme of work also includes a large component of vaccine hesitancy work. Updates will be presented on progress to date.

We will also take the opportunity to update you on upcoming studies within the portfolio and seek your input. These include:

  • Measles remains a common cause of morbidity and mortality in infants under five years worldwide, with occurrence substantially noted in regions with low vaccination rates. While it is generally believed infants are protected by maternal antibodies for 6-9 months, an over representation of infants under 6 months has been shown in recent outbreaks. Vaccination of infants earlier than the standard 9months with a booster dose may confer protection to these children earlier.BoostME trial: Earlier prime-boost schedule to improve measles protection in
    high burden settings.
  • A study to investigate risk factors that could be incorporated into routine care to prevent severe infant infection in the first days of life.The studies are conducted at the Several KCCA facilities including Kawempe National Referral Hospital, Kisenyi health centre IV, Kawala and Komomboga and others by investigators from MU-JHU and SGUL through the EDCTP, Medical Research Council and Bill and Belinda Gates Foundation funding.
Session facilitators
  • Prof. Kirsty Le Doare
  • Dr. Eve Nakabembe
  • Dr. Robert Mboizi
  • Dr. Solomon Kamurari
  • Dr. Hannah Davis
  • Dr. Ouma Joseph
  • Dr. Geoff Kitson
  • Dr. Mary Kyohere
  • Dr. Alexander Amone
  • Dr. Gerald Businge
  • Dr. Lauren Hookham
  • Dr. Agnes Ssali
  • Victoria Nambasa
  • Anthony Ssebagereka
  • Esther Imede
  • Sarah Sturrock
  • Phiona  Nalubega
  • Ritah Namugumya

Join Zoom Meeting:
https://us02web.zoom.us/j/88596947058?pwd=SHFUOHljTnpHMWxKd0VjcmR5emsrQT09
Meeting ID: 885 969

Details

Date:
May 12, 2023
Time:
7:45 am - 1:00 pm UTC+0
Event Tags:
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Organizer

MU-JHU Care Ltd
Phone:
+256 414 541 044 / +256 200 404 100
Email:
rmboizi@mujhu.org